When Your Brain's Immune System Burns Out: A New Way to Think About Alzheimer's Disease

What if Alzheimer's isn't just about the buildup of toxic proteins — but about the immune cells that were supposed to clean them up, and why they…

Mar 30 • Hussein Yassine

12

3

4

Red Meat, APOE4, and the Limits of Observational Nutrition Science

Observational studies can drive you nuts!

Mar 23 • Hussein Yassine

12

5

3

The Amyloid Hypothesis of Alzheimer's Disease: What is Validated, What is Missed, and What Comes Next

One of the most debated hypotheses in modern medicine

Mar 15 • Hussein Yassine

11

4

3

Hormone Replacement Therapy, Brain Health, and APOE4

Understanding the benefits, risks, and unanswered questions surrounding hormone therapy and cognitive aging.

Mar 8 • Hussein Yassine

15

2

2

February 2026

To Statin or Not To Statin for Alzheimer's?

Why the best case for statins in APOE4 is vascular, not “Alzheimer’s treatment”

Feb 23 • Hussein Yassine

13

2

2

cPLA2 and the Synapse

New human data on an inflammatory enzyme linked to cognitive impairment in Alzheimer's disease

Feb 16 • Hussein Yassine

8

2

Ketosis, weight loss, and the APOE ε4 brain

A 70-year-old man came for a second opinion on optimizing brain health.

Feb 8 • Hussein Yassine

21

3

4

Blood Pressure and Brain Health: Why When Matters as Much as How Much

I recently saw an 85-year-old man in clinic because his memory has been declining.

Feb 2 • Hussein Yassine

8

1

1

January 2026

Blood-Based Biomarkers for Alzheimer’s Disease: What They Reveal—and What Remains Uncertain

A 55-year-old woman sits across from me in clinic.

Jan 25 • Hussein Yassine

22

4

3

Why the New Food Pyramid Matters—Especially for the Brain

The new dietary guidelines arrive at a moment when nutrition science is finally catching up with biology.

Jan 17 • Hussein Yassine

10

4

5

Long Way to cPLA2: How a Nutrition Question Changed Our View of Alzheimer’s

As we enter a new year, I want to wish you a healthy 2026 and share a bit of the story behind our most recent paper (published online today).

Jan 7 • Hussein Yassine

9

4

3

December 2025

The Bend in the Curve: APOE ε4, Cognition, and Prevention

Merry Christmas, everyone.

Dec 20, 2025 • Hussein Yassine

9

1