Archive - Hussein N. Yassine

GLP-1 Microdosing for Inflammation and Longevity?

What the Evidence Means for Lean APOE4 Carriers

13 hrs ago • Hussein Yassine

Ceperognastat and the Limits of Tau Biomarker Translation

Tau PET tracks Alzheimer’s disease better than amyloid PET, but tracking disease is not the same as proving what will rescue the brain.

Aug 16 • Hussein Yassine

Why Aren’t We Giving APOE2 to APOE4 Carriers?

APOE2 may protect the aging brain, but it is not a simple genetic upgrade.

Aug 9 • Hussein Yassine

Protein Maxing Helps Muscle. But Does it Help Aging?

The Protein Longevity Paradox

Aug 1 • Hussein Yassine

July 2026

Exercise, Sitting, and APOE4

Why movement may matter most before symptoms begin — and what to do now.

Jul 26 • Hussein Yassine

P-tau217 and the Search for a Goldilocks Window in Alzheimer Prevention Trials

What a Major New Study Says About an Alzheimer’s Blood Test, and What It Doesn’t

Jul 21 • Hussein Yassine

A Reading of the MIND, FINGER, and US POINTER lifestyle interventions for AD

Progress, Missed Opportunities and Why Lifestyle Trials for Alzheimer’s Are So Hard to Get Right

Jul 12 • Hussein Yassine

How to Read A Study

Before You Believe the Headline

Jul 5 • Hussein Yassine

June 2026

Obicetrapib and the Biology of Alzheimer’s Prevention

BROADWAY showed a promising p-tau217 signal. The next test is whether a lipid drug can help the right biological population.

Jun 28 • Hussein Yassine

Beyond Omega-3 supplements: What PreventE4 Taught Us About Omega-3s and the Brain

Alzheimer’s prevention may depend on how the brain metabolizes omega-3s.

Jun 21 • Hussein Yassine

Of Mice and Men: The Rapamycin Problem in Alzheimer’s Prevention

Insights from tissue specific immune aging biomarkers

Jun 14 • Hussein Yassine

Alzheimer’s Inflammation: Treating a Fire We Still Can’t Measure

The MINDFuL trial: A Case Study in the Missing Inflammation Biomarker

Jun 7 • Hussein Yassine

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