Ketosis, weight loss, and the APOE ε4 brain

A 70-year-old man came for a second opinion on optimizing brain health.

Feb 8 • Hussein Yassine

13

3

3

Blood Pressure and Brain Health: Why When Matters as Much as How Much

I recently saw an 85-year-old man in clinic because his memory has been declining.

Feb 2 • Hussein Yassine

7

1

1

January 2026

Blood-Based Biomarkers for Alzheimer’s Disease: What They Reveal—and What Remains Uncertain

A 55-year-old woman sits across from me in clinic.

Jan 25 • Hussein Yassine

19

4

3

Why the New Food Pyramid Matters—Especially for the Brain

The new dietary guidelines arrive at a moment when nutrition science is finally catching up with biology.

Jan 17 • Hussein Yassine

9

4

4

Long Way to cPLA2: How a Nutrition Question Changed Our View of Alzheimer’s

As we enter a new year, I want to wish you a healthy 2026 and share a bit of the story behind our most recent paper (published online today).

Jan 7 • Hussein Yassine

9

4

3

December 2025

The Bend in the Curve: APOE ε4, Cognition, and Prevention

Merry Christmas, everyone.

Dec 20, 2025 • Hussein Yassine

8

1

From the Supplement Aisle to Evolving Science: Rethinking Omega-3s, Krill Oil, and Brain Health

I was at Costco recently, walking through the supplement aisle, when I noticed how much space is now devoted to krill oil and other omega-3 products.

Dec 15, 2025 • Hussein Yassine

12

2

Could a Shingles Vaccine Protect Your Brain? The Evidence Is Getting Hard to Ignore

This story starts with a simple but powerful idea: the brain’s immune cells can burn out. In Alzheimer’s disease, the main cleanup crew—microglia—spend…

Dec 8, 2025 • Hussein Yassine

5

Semaglutide trial failures in Alzheimer's: missed opportunities to test the metabolic hypothesis of AD

For almost a decade, scientists have been intrigued by the possibility that Alzheimer’s disease might be, at least in part, a disorder of brain energy…

Dec 1, 2025 • Hussein Yassine

4

2

November 2025

High dose omega-3s in end stage renal disease: what do we learn from the PISCES trial?

In the PISCES trial, 1,228 adults on long-term hemodialysis in Canada and Australia were randomized to receive either 4 grams per day of fish oil (1.6 g…

Nov 29, 2025 • Hussein Yassine

1

ApoE directed Therapeutics in Alzheimer's disease, SFN 2025

Alzheimer’s disease has historically been viewed through the lens of amyloid plaques and tau tangles, but accumulating evidence shows that these…

Nov 16, 2025 • Hussein Yassine

7

Coming soon

This is Hussein N. Yassine.

Nov 16, 2025 • Hussein Yassine

1