Thank you for this Dr Yassine for this work. I am glad you have support to follow this and many of us will watch your progress.
A question: Has there been any evidence that recommended inflammation lowering steps (diet, exercise, supplements, medication ) are effective in modulating cPLA2 or is this a process that will run its course and increase inflammation regardless of intervention? Thank you again.
So ideally, we can take LPC-DHA to gain modest entrance to the brain via whatever MFSD2A function we have going for us as APOE4 carriers, and then, when your cPLA2 inhibitor is in market, it can be put to good use, long enough for it to get where it needs to go! This is a really cool time to be alive, for us APOE4 carriers! Best wishes to you and your research teams in 2026!
Thank you for this Dr Yassine for this work. I am glad you have support to follow this and many of us will watch your progress.
A question: Has there been any evidence that recommended inflammation lowering steps (diet, exercise, supplements, medication ) are effective in modulating cPLA2 or is this a process that will run its course and increase inflammation regardless of intervention? Thank you again.
Thank you William! We do not know what modulates the activity of this enzyme. We know APOE4, ischemia and amyloid oligomers do.
So ideally, we can take LPC-DHA to gain modest entrance to the brain via whatever MFSD2A function we have going for us as APOE4 carriers, and then, when your cPLA2 inhibitor is in market, it can be put to good use, long enough for it to get where it needs to go! This is a really cool time to be alive, for us APOE4 carriers! Best wishes to you and your research teams in 2026!
Tremendous focus.