Thanks for your very clear and considered information. I noted a reference in this post to high cholesterol as a ‘second insult’, and wondered if you could help me with an explanation of exactly how high LDL endangers the E4 brain? I’m a 71 year old E4/E4 languishing at the bottom of the world in New Zealand, where there’s not a lot of help for us carriers. I’ve had a recent CAC test which was Zero, I have low blood pressure, and excellent metabolic health with no indication of heart trouble. My Ldl is high (over 200)but if the brain makes its own cholesterol entirely separately from that in the periphery, and I have no heart disease, why do I need to worry about Ldl contributing to dementia risk?
Great article (again) Dr. Yassine. This is very helpful.
Thanks for your very clear and considered information. I noted a reference in this post to high cholesterol as a ‘second insult’, and wondered if you could help me with an explanation of exactly how high LDL endangers the E4 brain? I’m a 71 year old E4/E4 languishing at the bottom of the world in New Zealand, where there’s not a lot of help for us carriers. I’ve had a recent CAC test which was Zero, I have low blood pressure, and excellent metabolic health with no indication of heart trouble. My Ldl is high (over 200)but if the brain makes its own cholesterol entirely separately from that in the periphery, and I have no heart disease, why do I need to worry about Ldl contributing to dementia risk?
Dear Megan
Thank you for sharing.
High cholesterol is a risk factor. I discuss it here: https://hyassine.substack.com/p/to-statin-or-not-to-statin-for-alzheimers?r=5ha6ys&utm_medium=ios
Many thanks- most helpful.