This is excellent! The optimism is much appreciated. ApoE4 people need more optimism and less doom and gloom. Unfortunately our culture reinforces sedentary behaviors - commutes, car based neighborhoods, travel, desk jobs, long restaurant meals, etc. I have found ways to offset the cultural bias towards sitting (I do not like sitting, a spine surgeon told me years ago when I had trouble with discs, “the spine does not like sitting”) - when I have to sit for more than 15-20 minutes I do isometric exercise, band work, core and breath work, and also use a blood flow restriction device/ kaatsu cycles.
> An important reminder that not all sedentary time is biologically equivalent. The real question may not be "How long do we sit?" but "What is the brain doing while we sit?" Exercise still matters, but cognitive engagement might be an underappreciated layer of brain health.
My mom died of late stage Alzheimer’s in January—lots of suffering for all. I have one APOE4 gene. This may be the single most important article explaining why movement matters I’ve read as a sports medicine doctor who thought getting in my 30 minute workout in was enough. I see now I need more. Thank you!!
This is excellent! The optimism is much appreciated. ApoE4 people need more optimism and less doom and gloom. Unfortunately our culture reinforces sedentary behaviors - commutes, car based neighborhoods, travel, desk jobs, long restaurant meals, etc. I have found ways to offset the cultural bias towards sitting (I do not like sitting, a spine surgeon told me years ago when I had trouble with discs, “the spine does not like sitting”) - when I have to sit for more than 15-20 minutes I do isometric exercise, band work, core and breath work, and also use a blood flow restriction device/ kaatsu cycles.
> An important reminder that not all sedentary time is biologically equivalent. The real question may not be "How long do we sit?" but "What is the brain doing while we sit?" Exercise still matters, but cognitive engagement might be an underappreciated layer of brain health.
My mom died of late stage Alzheimer’s in January—lots of suffering for all. I have one APOE4 gene. This may be the single most important article explaining why movement matters I’ve read as a sports medicine doctor who thought getting in my 30 minute workout in was enough. I see now I need more. Thank you!!
great explanation, summarization of the data and practical tips. I for one would say this is beneficial for all genotypes