As a double APOE4 carrier who lost both parents to FTD, I appreciate your conversation around this topic. My mom was a heavy drinker, especially in midlife but my father was a one drink per week guy. Both of them took stains for years for high cholesterol, had Afib, high stress and sleep apnea issues. I’d like to blame the alcohol to make myself feel like I can control my own personal outcome but I know that is wishful thinking. It’s all about the little choices that add up over time. Please keep sharing your findings. It brings me hope that my outcome could be different from theirs.
Seriously just not worth the risk. How about non alcohol beer? Are there ingredients that are not good for the brain. I do enjoy one of these every so often.
Great article as always! I like the mental model of APOE4 as a vulnerability state...impaired lipid transport generally creates more waste products that a high functioning brain can handle, but impaired sleep, alcohol, stress, age (all of the above) can keep the brain from returning to baseline and over time lead to degradation. That's not proven obviously, but I like that concept as a way to think about how to approach prevention
Did this woman sleep worse all the time (including 6 non-drinking nights) with one weekly glass of alcohol, or was she "only" experiencing sleep disturbance on the one night she had a glass of wine?
As a double APOE4 carrier who lost both parents to FTD, I appreciate your conversation around this topic. My mom was a heavy drinker, especially in midlife but my father was a one drink per week guy. Both of them took stains for years for high cholesterol, had Afib, high stress and sleep apnea issues. I’d like to blame the alcohol to make myself feel like I can control my own personal outcome but I know that is wishful thinking. It’s all about the little choices that add up over time. Please keep sharing your findings. It brings me hope that my outcome could be different from theirs.
Seriously just not worth the risk. How about non alcohol beer? Are there ingredients that are not good for the brain. I do enjoy one of these every so often.
Non alcohol beer is great!
Great article as always! I like the mental model of APOE4 as a vulnerability state...impaired lipid transport generally creates more waste products that a high functioning brain can handle, but impaired sleep, alcohol, stress, age (all of the above) can keep the brain from returning to baseline and over time lead to degradation. That's not proven obviously, but I like that concept as a way to think about how to approach prevention
Did this woman sleep worse all the time (including 6 non-drinking nights) with one weekly glass of alcohol, or was she "only" experiencing sleep disturbance on the one night she had a glass of wine?
I do not want to reveal more info! She is probably reading this post and laughing. But let's say more than once a week drinking to no drinking...